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RNA-destabilizing Factor Tristetraprolin Negatively Regulates NF-κB Signaling
Tristetraprolin (TTP) is a CCCH zinc finger-containing protein that destabilizes mRNA by binding to an AU-rich element. Mice deficient in TTP develop a severe inflammatory syndrome mainly because of overproduction of tumor necrosis factor α. We report here that TTP also negatively regulates NF-κB si...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2009
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2785570/ https://ncbi.nlm.nih.gov/pubmed/19738286 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.024745 |
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