Interaction of nilotinib, dasatinib and bosutinib with ABCB1 and ABCG2: implications for altered anti-cancer effects and pharmacological properties

BACKGROUND AND PURPOSE: ABC multidrug transporters (MDR-ABC proteins) cause multiple drug resistance in cancer and may be involved in the decreased anti-cancer efficiency and modified pharmacological properties of novel specifically targeted agents. It has been documented that ABCB1 and ABCG2 intera...

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Detalhes bibliográficos
Main Authors: Hegedűs, C, Özvegy-Laczka, C, Apáti, Á, Magócsi, M, Német, K, Őrfi, L, Kéri, G, Katona, M, Takáts, Z, Váradi, A, Szakács, G, Sarkadi, B
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2009
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785536/
https://ncbi.nlm.nih.gov/pubmed/19785662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2009.00383.x
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