YB-1 Acts as a Ligand for Notch-3 Receptors and Modulates Receptor Activation

Y-box (YB) protein-1 is secreted by mesangial and immune cells after cytokine challenge, but extracellular functions are unknown. Here, we demonstrate that extracellular YB-1 associates with outer cell membrane components and interacts with extracellular Notch-3 receptor domains. The interaction app...

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Detalhes bibliográficos
Main Authors: Rauen, Thomas, Raffetseder, Ute, Frye, Björn C., Djudjaj, Sonja, Mühlenberg, Philipp J. T., Eitner, Frank, Lendahl, Urban, Bernhagen, Jürgen, Dooley, Steven, Mertens, Peter R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Mechanisms of Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785380/
https://ncbi.nlm.nih.gov/pubmed/19640841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.046599
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