Structure of Signal-regulatory Protein α: A LINK TO ANTIGEN RECEPTOR EVOLUTION

Signal-regulatory protein α (SIRPα) is a myeloid membrane receptor that interacts with the membrane protein CD47, a marker of self. We have solved the structure of the complete extracellular portion of SIRPα, comprising three immunoglobulin superfamily domains, by x-ray crystallography to 2.5 Å reso...

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Detalhes bibliográficos
Main Authors: Hatherley, Deborah, Graham, Stephen C., Harlos, Karl, Stuart, David I., Barclay, A. Neil
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785349/
https://ncbi.nlm.nih.gov/pubmed/19628875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.017566
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