RAGE-mediated signaling contributes to intraneuronal transport of amyloid-β and neuronal dysfunction

Intracellular amyloid-β peptide (Aβ) has been implicated in neuronal death associated with Alzheimer's disease. Although Aβ is predominantly secreted into the extracellular space, mechanisms of Aβ transport at the level of the neuronal cell membrane remain to be fully elucidated. We demonstrate...

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Detalhes bibliográficos
Main Authors: Takuma, Kazuhiro, Fang, Fang, Zhang, Wensheng, Yan, Shiqiang, Fukuzaki, Emiko, Du, Heng, Sosunov, Alexander, McKhann, Guy, Funatsu, Yoko, Nakamichi, Noritaka, Nagai, Taku, Mizoguchi, Hiroyuki, Ibi, Daisuke, Hori, Osamu, Ogawa, Satoshi, Stern, David M., Yamada, Kiyofumi, Yan, Shirley ShiDu
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785285/
https://ncbi.nlm.nih.gov/pubmed/19901339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0905686106
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