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Effect of Anaplerotic Fluxes and Amino Acid Availability on Hepatic Lipoapoptosis

To identify metabolic pathways involved in hepatic lipoapoptosis, metabolic flux analysis using [U-(13)C(5)]glutamine as an isotopic tracer was applied to quantify phenotypic changes in H4IIEC3 hepatoma cells treated with either palmitate alone (PA-cells) or both palmitate and oleate in combination...

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Detalhes bibliográficos
Main Authors: Noguchi, Yasushi, Young, Jamey D., Aleman, Jose O., Hansen, Michael E., Kelleher, Joanne K., Stephanopoulos, Gregory
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785187/
https://ncbi.nlm.nih.gov/pubmed/19758988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.049478
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