Cyclin D1 Induction by Benzo[a]pyrene-7,8-diol-9,10-epoxide via the Phosphatidylinositol 3-Kinase/Akt/MAPK- and p70(s6k)-dependent Pathway Promotes Cell Transformation and Tumorigenesis

Benzo[a]pyrene-7,8-diol-9,10-epoxide (B[a]PDE), the major metabolite of B[a]P, has been well recognized as one ubiquitous carcinogen, but the molecular mechanism involved in its carcinogenic effect remains obscure. In the present study, we found that bronchial epithelial cells (Beas-2B) and hepatocy...

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Autores principales: Ding, Jin, Ning, Beifang, Gong, Wenfeng, Wen, Wen, Wu, Kun, Liang, Junqing, He, Guoping, Huang, Shanna, Sun, Wen, Han, Tao, Huang, Lei, Cao, Guangwen, Wu, Mengchao, Xie, Weifen, Wang, Hongyang
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2009
Materias:
Mechanisms of Signal Transduction
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785174/
https://ncbi.nlm.nih.gov/pubmed/19801633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.046417
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