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Extracellular 2′,3′-cAMP Is a Source of Adenosine

We discovered that renal injury releases 2′,3′-cAMP (positional isomer of 3′,5′-cAMP) into the interstitium. This finding motivated a novel hypothesis: renal injury leads to activation of an extracellular 2′,3′-cAMP-adenosine pathway (i.e. metabolism of extracellular 2′,3′-cAMP to 3′-AMP and 2′-AMP,...

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Bibliografiske detaljer
Main Authors: Jackson, Edwin K., Ren, Jin, Mi, Zaichuan
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785151/
https://ncbi.nlm.nih.gov/pubmed/19801686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.053876
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