Membrane-bound but not Secreted Fas Ligand Is Essential for Fas-Induced Apoptosis and Prevention of Autoimmunity and Cancer

Fas ligand (FasL), an apoptosis-inducing member of the TNF cytokine family and its receptor, Fas, are critical for shutdown of chronic immune responses1-3 and prevention of autoimmunity4,5. Accordingly, mutations in their genes cause severe lymphadenopathy and autoimmune disease in mice6,7 and human...

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Auteurs principaux: O' Reilly, Lorraine A., Tai, Lin, Lee, Lily, Kruse, Elizabeth A., Grabow, Stephanie, Fairlie, W Douglas, Haynes, Nicole M., Tarlinton, David M., Zhang, Jian-Guo, Belz, Gabrielle T., Smyth, Mark J., Bouillet, Philippe, Robb, Lorraine, Strasser, Andreas
Format: Artigo
Langue:Inglês
Publié: 2009
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785124/
https://ncbi.nlm.nih.gov/pubmed/19794494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature08402
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