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A novel fluorescent probe for the detection of myeloperoxidase activity in atherosclerosis-associated macrophages
The myeloperoxidase (MPO)-derived oxidant hypochlorous acid (HOCl/OCl(−)) is implicated in the pathogenesis of atherosclerosis and other inflammatory states. We have synthesized a novel imaging probe, sulfonaphthoaminophenyl fluorescein (SNAPF), that selectively reacts to HOCl. SNAPF detects HOCl pr...
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| Main Authors: | , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2007
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2785040/ https://ncbi.nlm.nih.gov/pubmed/18022561 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2007.10.005 |
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