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A novel fluorescent probe for the detection of myeloperoxidase activity in atherosclerosis-associated macrophages

The myeloperoxidase (MPO)-derived oxidant hypochlorous acid (HOCl/OCl(−)) is implicated in the pathogenesis of atherosclerosis and other inflammatory states. We have synthesized a novel imaging probe, sulfonaphthoaminophenyl fluorescein (SNAPF), that selectively reacts to HOCl. SNAPF detects HOCl pr...

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Main Authors: Shepherd, Joanna, Hilderbrand, Scott A., Waterman, Peter, Heinecke, Jay W., Weissleder, Ralph, Libby, Peter
格式: Artigo
語言:Inglês
出版: 2007
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785040/
https://ncbi.nlm.nih.gov/pubmed/18022561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2007.10.005
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