QUANTIFICATION OF TRYPTOPHAN TRANSPORT AND METABOLISM IN LUNG TUMORS USING POSITRON EMISSION TOMOGRAPHY

RATIONALE: Abnormal tryptophan metabolism catalyzed by indoleamine 2,3-dioxygenase (IDO) may play a prominent role in tumor immuno-resistance in many tumor types, including lung tumors. The goal of this study was to evaluate in vivo kinetics of [Formula: see text] [(11)C]methyl-L-tryptophan (AMT), a...

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Main Authors: Juhász, Csaba, Muzik, Otto, Lu, Xin, Jahania, M. Salik, Soubani, Ayman O., Khalaf, Majid, Peng, Fangyu, Mangner, Thomas J., Chakraborty, Pulak K., Chugani, Diane C.
Format: Artigo
Jezik:Inglês
Izdano: 2009
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2784997/
https://ncbi.nlm.nih.gov/pubmed/19223408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.108.058776
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