Identification and Characterization of a Small Molecule Inhibitor of Formin-Mediated Actin Assembly

Formins stimulate actin filament assembly for fundamental cellular processes including division, adhesion, establishing polarity and motility. A formin inhibitor would be useful because most cells express multiple formins whose functions are not known, and because metastatic tumor formation depends...

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Autores principales: Rizvi, Syed A., Neidt, Erin M., Cui, Jiayue, Feiger, Zach, Skau, Colleen T., Gardel, Margaret L., Kozmin, Sergey A., Kovar, David R.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2009
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2784894/
https://ncbi.nlm.nih.gov/pubmed/19942139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2009.10.006
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