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Influence of processing-induced phase transformations on the dissolution of theophylline tablets

The object of this investigation was to evaluate the influence of (1) processing-induced decrease in drug crystallinity and (2) phase transformations during dissolution, on the per-formance of theophylline tablet formulations. Anhydrous theophylline underwent multiple transformations (anhydrate »hyd...

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Detalhes bibliográficos
Main Authors: Debnath, Smita, Suryanarayanan, Raj
Formato: Artigo
Idioma:Inglês
Publicado em: Springer-Verlag 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2784859/
https://ncbi.nlm.nih.gov/pubmed/15198529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/pt050108
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