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N6-Substituted cAMP Analogs Inhibit bTREK-1 K(+) Channels and Stimulate Cortisol Secretion by a Protein Kinase A-Independent Mechanism
Bovine adrenal zona fasciculata (AZF) cells express bTREK-1 K(+) channels whose inhibition by cAMP is coupled to membrane depolarization and cortisol secretion through complex signaling mechanisms. cAMP analogs with substitutions in the 6 position of the adenine ring selectively activate cAMP-depend...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Pharmacology and Experimental Therapeutics
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2784727/ https://ncbi.nlm.nih.gov/pubmed/19734321 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.109.057075 |
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