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Development of Non-alcoholic Steatohepatitis in Insulin Resistant L-SACC1 Mice
BACKGROUND & AIMS: Liver-specific inactivation of CEACAM1 causes hyperinsulinemia and insulin resistance, which result from impaired insulin clearance, in L-SACC1 transgenic mice. These mice also develop steatosis. Because hepatic fat accumulation precedes hepatitis, lipid peroxidation and apopt...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2784638/ https://ncbi.nlm.nih.gov/pubmed/18848945 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2008.08.007 |
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