Development of Non-alcoholic Steatohepatitis in Insulin Resistant L-SACC1 Mice

BACKGROUND & AIMS: Liver-specific inactivation of CEACAM1 causes hyperinsulinemia and insulin resistance, which result from impaired insulin clearance, in L-SACC1 transgenic mice. These mice also develop steatosis. Because hepatic fat accumulation precedes hepatitis, lipid peroxidation and apopt...

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Main Authors: Lee, Sang Jun, Heinrich, Garrett, Fedorova, Larisa, Al-Share, Qusai Y., Ledford, Kelly J., Fernstrom, Mats A., McInerney, Marcia F., Erickson, Sandra K., Gatto-Weis, Cara, Najjar, Sonia M.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2784638/
https://ncbi.nlm.nih.gov/pubmed/18848945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2008.08.007
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