Electrophilic Peroxisome Proliferator–Activated Receptor-γ Ligands Have Potent Antifibrotic Effects in Human Lung Fibroblasts

Pulmonary fibrosis is a progressive scarring disease with no effective treatment. Transforming growth factor (TGF)-β is up-regulated in fibrotic diseases, where it stimulates differentiation of fibroblasts to myofibroblasts and production of excess extracellular matrix. Peroxisome proliferator–activ...

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Main Authors: Ferguson, Heather E., Kulkarni, Ajit, Lehmann, Geniece M., Garcia-Bates, Tatiana M., Thatcher, Thomas H., Huxlin, Krystel R., Phipps, Richard P., Sime, Patricia J.
Formato: Artigo
Idioma:Inglês
Publicado: American Thoracic Society 2009
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2784409/
https://ncbi.nlm.nih.gov/pubmed/19286977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2009-0006OC
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