Antifibrotic Actions of Peroxisome Proliferator-Activated Receptor γ Ligands in Corneal Fibroblasts Are Mediated by β-Catenin–Regulated Pathways

Wound healing after corneal injury typically involves fibrosis, with transforming growth factor β1 (TGF-β1) as one of its strongest mediators. A class of small molecules—peroxisome proliferator–activated receptor γ (PPARγ) ligands—exert potent antifibrotic effects in the cornea by blocking phosphory...

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Detalles Bibliográficos
Publicado en:Am J Pathol
Main Authors: Jeon, Kye-Im, Phipps, Richard P., Sime, Patricia J., Huxlin, Krystel R.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Investigative Pathology 2017
Assuntos:
Short Communication
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5530905/
https://ncbi.nlm.nih.gov/pubmed/28606794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2017.04.002
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