Targeted next-generation sequencing of a cancer transcriptome enhances detection of sequence variants and novel fusion transcripts

Targeted RNA-Seq combines next-generation sequencing with capture of sequences from a relevant subset of a transcriptome. When testing by capturing sequences from a tumor cDNA library by hybridization to oligonucleotide probes specific for 467 cancer-related genes, this method showed high selectivit...

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Bibliografiske detaljer
Main Authors: Levin, Joshua Z, Berger, Michael F, Adiconis, Xian, Rogov, Peter, Melnikov, Alexandre, Fennell, Timothy, Nusbaum, Chad, Garraway, Levi A, Gnirke, Andreas
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2009
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Method
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2784330/
https://ncbi.nlm.nih.gov/pubmed/19835606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2009-10-10-r115
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