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Mechanistic Insights into Folic Acid-dependent Vascular Protection: Dihydrofolate reductase-mediated Reduction in Oxidant Stress in Endothelial Cells and Angiotensin II-Infused Mice: A Novel HPLC-based Fluorescent Assay for DHFR Activity
BACKGROUND: Folate supplementation improves endothelial function in patients with hyperhomocysteinemia. Mechanistic insights into potential benefits of folate on vascular function in general population however, remain mysterious. METHODS AND RESULTS: Expression of dihydrofolate reductase (DHFR) was...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2784291/ https://ncbi.nlm.nih.gov/pubmed/19660467 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2009.07.025 |
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