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Synthesis and In Vitro Evaluation of Aspartate Transcarbamoylase Inhibitors

The design, synthesis, and evaluation of a series of novel inhibitors of aspartate transcarbamoylase (ATCase) are reported. Several submicromolar phosphorus-containing inhibitors are described, but all-carboxylate compounds are inactive. Compounds were synthesized to probe the postulated cyclic tran...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Coudray, Laëtitia, Pennebaker, Anne F., Montchamp, Jean-Luc
פורמט: Artigo
שפה:Inglês
יצא לאור: 2009
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2783949/
https://ncbi.nlm.nih.gov/pubmed/19828320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2009.09.045
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