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Synthesis and In Vitro Evaluation of Aspartate Transcarbamoylase Inhibitors
The design, synthesis, and evaluation of a series of novel inhibitors of aspartate transcarbamoylase (ATCase) are reported. Several submicromolar phosphorus-containing inhibitors are described, but all-carboxylate compounds are inactive. Compounds were synthesized to probe the postulated cyclic tran...
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| Autors principals: | , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2009
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2783949/ https://ncbi.nlm.nih.gov/pubmed/19828320 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2009.09.045 |
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