Multivalent Binding Oligomers Inhibit HIV Tat-TAR Interaction Critical for Viral Replication

We describe the development of a new type of scaffold to target RNA structures. Multivalent binding oligomers (MBOs) are molecules in which multiple sidechains extend from a polyamine backbone such that favorable RNA binding occurs. We have used this strategy to develop MBO-based inhibitors to preve...

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Main Authors: Wang, Deyun, Iera, Jaclyn, Baker, Heather, Hogan, Priscilla, Ptak, Roger, Yang, Lu, Hartman, Tracy, Buckheit, Robert W., Desjardins, Alexandre, Yang, Ao, Legault, Pascale, Yedavalli, Venkat, Jeang, Kuan-Teh, Appella, Daniel H.
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2783946/
https://ncbi.nlm.nih.gov/pubmed/19896372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.10.078
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