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Methionine Sulfoxide Reductase A (MsrA) restores α-crystallin chaperone activity lost upon methionine oxidation

BACKGROUND: Lens cataract is associated with protein oxidation and aggregation. Two proteins that cause cataract when deleted from the lens are methionine sulfoxide reductase A (MsrA) that repairs protein methionine sulfoxide (PMSO) oxidized proteins and α-crystallin which is a two subunit (αA and α...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Brennan, Lisa A, Lee, Wanda, Giblin, Frank J, David, Larry L, Kantorow, Marc
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2783866/
https://ncbi.nlm.nih.gov/pubmed/19733220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagen.2009.08.011
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