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Mammals Reduce Methionine-S-sulfoxide with MsrA and Are Unable to Reduce Methionine-R-sulfoxide, and This Function Can Be Restored with a Yeast Reductase

Methionine is an essential amino acid in mammals at the junction of methylation, protein synthesis, and sulfur pathways. However, this amino acid is highly susceptible to oxidation, resulting in a mixture of methionine-S-sulfoxide and methionine-R-sulfoxide. Whether methionine is quantitatively rege...

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Detalhes bibliográficos
Main Authors: Lee, Byung Cheon, Le, Dung Tien, Gladyshev, Vadim N.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2568918/
https://ncbi.nlm.nih.gov/pubmed/18697736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M805059200
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