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Arsenicals Produce Stable Progressive Changes in DNA Methylation Patterns that are Linked to Malignant Transformation of Immortalized Urothelial Cells

Aberrant DNA methylation participates in carcinogenesis and is a molecular hallmark of a tumor cell. Tumor cells generally exhibit a redistribution of DNA methylation resulting in global hypomethylation with regional hypermethylation; however, the speed in which these changes emerge has not been ful...

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Hlavní autoři: Jensen, Taylor J., Novak, Petr, Wnek, Shawn M., Gandolfi, A. Jay, Futscher, Bernard W.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2783766/
https://ncbi.nlm.nih.gov/pubmed/19716837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2009.08.019
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