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Abasic Site-Containing DNAzyme and Aptamer for Label-free Fluorescent Detection of Pb(2+) and Adenosine with High Sensitivity, Selectivity and Tunable Dynamic Range

An abasic site called dSpacer has been introduced into duplex regions of the 8–17 DNAzyme and adenosine aptamer for label-free fluorescent detection of Pb(2+) and adenosine, respectively. The dSpacer can bind an extrinsic fluorescent compound, 2-amino-5,6,7-trimethyl-1,8-naphthyridine (ATMND), and q...

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Autori principali: Xiang, Yu, Tong, Aijun, Lu, Yi
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2783749/
https://ncbi.nlm.nih.gov/pubmed/19807110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja905854a
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