Activation of the PI3K/AKT pathway induces urothelial carcinoma of the renal pelvis: Identification in human tumors and confirmation in animal models

Urothelial carcinoma of the renal pelvis is a deadly disease with an unclear tumorigenic mechanism. We conducted gene expression profiling on a set of human tumors of this type, and identified a PI3K/AKT activation expression signature in 76.9% (n=13) of our samples. Sequence analysis found both act...

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Detalhes bibliográficos
Main Authors: Qian, Chao-Nan, Furge, Kyle A., Knol, Jared, Huang, Dan, Chen, Jindong, Dykema, Karl J., Kort, Eric J., Massie, Aaron, Khoo, Sok Kean, VandenBeldt, Kristin, Resau, James H., Anema, John, Kahnoski, Richard J., Morreau, Hans, Camparo, Philippe, Comperat, Eva, Sibony, Mathilde, Denoux, Yves, Molinie, Vincent, Vieillefond, Annick, Eng, Charis, Williams, Bart O., Teh, Bin Tean
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2783739/
https://ncbi.nlm.nih.gov/pubmed/19843858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-1689
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