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Energetics of Displacing Water Molecules from Protein Binding Sites: Consequences for Ligand Optimization
A strategy in drug design is to consider enhancing the affinity of lead molecules with structural modifications that displace water molecules from a protein binding site. Because success of the approach is uncertain, clarification of the associated energetics was sought in cases where similar struct...
Gorde:
| Egile Nagusiak: | , , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
2009
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2783447/ https://ncbi.nlm.nih.gov/pubmed/19778066 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja906058w |
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