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THE USE OF NANOPARTICLE-MEDIATED TARGETED GENE SILENCING AND DRUG DELIVERY TO OVERCOME TUMOR DRUG RESISTANCE
Overexpression of drug efflux transporters such as P-glycoprotein (P-gp) enables cancer cells to develop resistance to multiple anticancer drugs. Functional inhibitors of P-gp have shown promising efficacy in early clinical trials, but their long-term safety is yet to be established. A novel approac...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2783414/ https://ncbi.nlm.nih.gov/pubmed/19800114 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2009.09.048 |
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