Minocycline suppresses morphine-induced respiratory depression, suppresses morphine-induced reward, and enhances systemic morphine-induced analgesia

Recent data suggest that opioids can activate immune-like cells of the central nervous system (glia). This opioid-induced glial activation is associated with decreased analgesia, owing to the release of proinflammatory mediators. Here we examine in rats whether the putative microglial inhibitor, min...

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Hauptverfasser: Hutchinson, Mark R., Northcutt, Alexis L., Chao, Lindsey W., Kearney, Jeffrey J., Zhang, Yingning, Berkelhammer, Debra L., Loram, Lisa C., Rozeske, Robert R., Bland, Sondra T., Maier, Steven F., Gleeson, Todd T., Watkins, Linda R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2783326/
https://ncbi.nlm.nih.gov/pubmed/18706994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbi.2008.07.008
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