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Formation of γ-ketoaldehyde-protein adducts during ethanol-induced liver injury in mice

Ethanol metabolism promotes formation of a variety of reactive aldehydes in the liver. These aldehydes can rapidly form covalent protein adducts. Accumulating evidence indicates that these protein adducts may contribute to ethanol-mediated liver injury. Overproduction of γ-ketoaldehydes, levuglandin...

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Detalhes bibliográficos
Main Authors: Roychowdhury, Sanjoy, McMullen, Megan R., Pritchard, Michele T., Li, Wei, Salomon, Robert G., Nagy, Laura E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2783279/
https://ncbi.nlm.nih.gov/pubmed/19616618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2009.07.015
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