Delphinidin suppresses ultraviolet B-induced cyclooxygenases-2 expression through inhibition of MAPKK4 and PI-3 kinase

Cyclooxygenase-2 (COX-2), a key mediator of inflammation, and its product, prostaglandin E(2) (PGE(2)), enhance carcinogenesis, particularly in skin. Ultraviolet (UV) B is the most carcinogenic component of solar irradiation, and a crucial role of COX-2 in UVB-mediated skin carcinogenesis has been r...

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Detalles Bibliográficos
Main Authors: Kwon, Jung Yeon, Lee, Ki Won, Kim, Jong-Eun, Jung, Sung Keun, Kang, Nam Joo, Hwang, Mun Kyung, Heo, Yong-Seok, Bode, Ann M., Dong, Zigang, Lee, Hyong Joo
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2009
Assuntos:
Cancer Prevention
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2783004/
https://ncbi.nlm.nih.gov/pubmed/19776176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgp216
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