β-Cell–Mediated Signaling Predominates Over Direct α-Cell Signaling in the Regulation of Glucagon Secretion in Humans

OBJECTIVE: Given evidence of both indirect and direct signaling, we tested the hypothesis that increased β-cell–mediated signaling of α-cells negates direct α-cell signaling in the regulation of glucagon secretion in humans. RESEARCH DESIGN AND METHODS: We measured plasma glucagon concentrations bef...

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Bibliographic Details
Main Authors: Cooperberg, Benjamin A., Cryer, Philip E.
Format: Artigo
Language:Inglês
Published: American Diabetes Association 2009
Subjects:
Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2782990/
https://ncbi.nlm.nih.gov/pubmed/19729529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/dc09-0798
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