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Impairment in Reactivation of a Latency Associated Transcript (LAT)-Deficient HSV-2 is Not Solely Dependent on the Latent Viral Load or the Number of CD8(+)T Cells Infiltrating the Ganglia

The HSV latency-associated transcript (LAT) is abundantly expressed during virus latency. Previous studies have shown that the latent viral load and CD8(+)T cells in ganglia influence the rate of reactivation of HSV. While LAT is important for efficient reactivation and establishment of latency, it...

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Dettagli Bibliografici
Autori principali: Hoshino, Yo, Pesnicak, Lesley, Straus, Stephen E., Cohen, Jeffrey I.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2782611/
https://ncbi.nlm.nih.gov/pubmed/19269661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2009.02.004
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