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Guanidinoneomycin B Recognition of an HIV-1 RNA Helix

Aminoglycoside antibiotics are small-molecule drugs that bind RNA. The affinity and specificity of aminoglycoside binding to RNA can be increased through chemical modification, such as guanidinylation. Here, we report the binding of guanidinoneomycin B (GNB) to an RNA helix from the HIV-1 frameshift...

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Bibliografiske detaljer
Main Authors: Staple, David W., Venditti, Vincenzo, Niccolai, Neri, Elson-Schwab, Lev, Tor, Yitzhak, Butcher, Samuel E.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2782590/
https://ncbi.nlm.nih.gov/pubmed/18058789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.200700251
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