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Guanidinoneomycin B Recognition of an HIV-1 RNA Helix
Aminoglycoside antibiotics are small-molecule drugs that bind RNA. The affinity and specificity of aminoglycoside binding to RNA can be increased through chemical modification, such as guanidinylation. Here, we report the binding of guanidinoneomycin B (GNB) to an RNA helix from the HIV-1 frameshift...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2008
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2782590/ https://ncbi.nlm.nih.gov/pubmed/18058789 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.200700251 |
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