Low-Dose Metronomic Cyclophosphamide Combined with Vascular Disrupting Therapy Induces Potent Anti-Tumor Activity in Preclinical Human Tumor Xenograft Models

PURPOSE: Vascular disrupting agents (VDAs) preferentially target the established but abnormal tumor vasculature, resulting in extensive intratumoral hypoxia and cell death. However, a rim of viable tumor tissue remains from which angiogenesis-dependent regrowth can occur, in part via mobilization an...

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Bibliographic Details
Main Authors: Daenen, Laura G., Shaked, Yuval, Man, Shan, Xu, Ping, Voest, Emile E., Hoffman, Robert M., Chaplin, David, Kerbel, Robert S.
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2782518/
https://ncbi.nlm.nih.gov/pubmed/19825805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-09-0583
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