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Phosphorylation alters the pharmacology of Ca(2+)-activated Cl(−) channels in rabbit pulmonary arterial smooth muscle cells

BACKGROUND AND PURPOSE: Ca(2+)-activated Cl(−) currents (I(Cl(Ca))) in arterial smooth muscle cells are inhibited by phosphorylation. The Ca(2+)-activated Cl(−) channel (Cl(Ca)) blocker niflumic acid (NFA) produces a paradoxical dual effect on I(Cl(Ca)), causing stimulation or inhibition at potentia...

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Détails bibliographiques
Auteurs principaux: Wiwchar, M, Ayon, R, Greenwood, IA, Leblanc, N
Format: Artigo
Langue:Inglês
Publié: Blackwell Publishing Ltd 2009
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2782345/
https://ncbi.nlm.nih.gov/pubmed/19785656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2009.00405.x
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