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Conformational changes and flexibility in T-cell receptor recognition of peptide–MHC complexes

A necessary feature of the immune system, TCR (T-cell receptor) cross-reactivity has been implicated in numerous autoimmune pathologies and is an underlying cause of transplant rejection. Early studies of the interactions of αβ TCRs (T-cell receptors) with their peptide–MHC ligands suggested that co...

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Autori principali: Armstrong, Kathryn M., Piepenbrink, Kurt H., Baker, Brian M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Portland Press Ltd. 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2782316/
https://ncbi.nlm.nih.gov/pubmed/18800968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20080850
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