Rapid detection of ERG11 gene mutations in clinical Candida albicans isolates with reduced susceptibility to fluconazole by rolling circle amplification and DNA sequencing

BACKGROUND: Amino acid substitutions in the target enzyme Erg11p of azole antifungals contribute to clinically-relevant azole resistance in Candida albicans. A simple molecular method for rapid detection of ERG11 gene mutations would be an advantage as a screening tool to identify potentially-resist...

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Detalhes bibliográficos
Main Authors: Wang, Huiping, Kong, Fanrong, Sorrell, Tania C, Wang, Bin, McNicholas, Paul, Pantarat, Namfon, Ellis, David, Xiao, Meng, Widmer, Fred, Chen, Sharon CA
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2009
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Research article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2782262/
https://ncbi.nlm.nih.gov/pubmed/19682357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2180-9-167
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