Inhibition of Lysine Acetyltransferase KAT3B/p300 Activity by a Naturally Occurring Hydroxynaphthoquinone, Plumbagin

Lysine acetyltransferases (KATs), p300 (KAT3B), and its close homologue CREB-binding protein (KAT3A) are probably the most widely studied KATs with well documented roles in various cellular processes. Hence, the dysfunction of p300 may result in the dysregulation of gene expression leading to the ma...

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Hauptverfasser: Ravindra, Kodihalli C., Selvi, B. Ruthrotha, Arif, Mohammed, Reddy, B. A. Ashok, Thanuja, Gali R., Agrawal, Shipra, Pradhan, Suman Kalyan, Nagashayana, Natesh, Dasgupta, Dipak, Kundu, Tapas K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2009
Schlagworte:
Transcription, Chromatin, and Epigenetics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2782038/
https://ncbi.nlm.nih.gov/pubmed/19570987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.023861
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