On the Mechanism of Multiple Lysine Methylation by the Human Mixed Lineage Leukemia Protein-1 (MLL1) Core Complex

Transcription in eukaryotic genomes depends on enzymes that regulate the degree of histone H3 lysine 4 (H3K4) methylation. The mixed lineage leukemia protein-1 (MLL1) is a member of the SET1 family of H3K4 methyltransferases and is frequently rearranged in acute leukemias. Despite sequence compariso...

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Bibliographic Details
Main Authors: Patel, Anamika, Dharmarajan, Venkatasubramanian, Vought, Valarie E., Cosgrove, Michael S.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Transcription, Chromatin, and Epigenetics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2782018/
https://ncbi.nlm.nih.gov/pubmed/19556245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.014498
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