MyD88 Adapter-like (Mal)/TIRAP Interaction with TRAF6 Is Critical for TLR2- and TLR4-mediated NF-κB Proinflammatory Responses

Toll/interleukin-1 (TIR)receptor-containing adapters are critical in orchestrating the different signal transduction pathways following Toll-like receptor (TLR) activation. MyD88 adapter-like (Mal), also termed TIRAP, is involved in bridging MyD88 to the receptor complex for TLR-2 and TLR4 signaling...

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Autores principales: Verstak, Brett, Nagpal, Kamalpreet, Bottomley, Stephen P., Golenbock, Douglas T., Hertzog, Paul J., Mansell, Ashley
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2009
Materias:
Mechanisms of Signal Transduction
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2782013/
https://ncbi.nlm.nih.gov/pubmed/19592497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.023044
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