Camptothecin and khat (Catha edulis Forsk.) induced distinct cell death phenotypes involving modulation of c-FLIP(L), Mcl-1, procaspase-8 and mitochondrial function in acute myeloid leukemia cell lines

BACKGROUND: An organic extract of the recreational herb khat (Catha edulis Forsk.) triggers cell death in various leukemia cell lines in vitro. The chemotherapeutics camptothecin, a plant alkaloid topoisomerase I inhibitor, was tested side-by-side with khat in a panel of acute myeloid leukemia cell...

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Библиографические подробности
Главные авторы: Bredholt, Therese, Dimba, Elizabeth AO, Hagland, Hanne R, Wergeland, Line, Skavland, Jørn, Fossan, Kjell O, Tronstad, Karl J, Johannessen, Anne C, Vintermyr, Olav K, Gjertsen, Bjørn T
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2009
Предметы:
Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2781802/
https://ncbi.nlm.nih.gov/pubmed/19912650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-8-101
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