Crystal Structure and Catalytic Mechanism of 4-Methylmuconolactone Methylisomerase

When methyl-substituted aromatic compounds are degraded via ortho (intradiol)-cleavage of 4-methylcatechol, the dead-end metabolite 4-methylmuconolactone (4-ML) is formed. Degradation of 4-ML has only been described in few bacterial species, including Pseudomonas reinekei MT1. The isomerization of 4...

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Autores principales: Marín, Macarena, Heinz, Dirk W., Pieper, Dietmar H., Klink, Björn U.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2009
Materias:
Protein Structure and Folding
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2781687/
https://ncbi.nlm.nih.gov/pubmed/19801657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.024604
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