T Cell Receptor Signaling Co-regulates Multiple Golgi Genes to Enhance N-Glycan Branching

T cell receptor (TCR) signaling enhances β1,6GlcNAc-branching in N-glycans, a phenotype that promotes growth arrest and inhibits autoimmunity by increasing surface retention of cytotoxic T lymphocyte antigen-4 (CTLA-4) via interactions with galectins. N-Acetylglucosaminyltransferase V (MGAT5) mediat...

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Detalhes bibliográficos
Main Authors: Chen, Hung-Lin, Li, Carey Fei, Grigorian, Ani, Tian, Wenqiang, Demetriou, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Glycobiology and Extracellular Matrices
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2781660/
https://ncbi.nlm.nih.gov/pubmed/19706602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.023630
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