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CK1α Plays a Central Role in Mediating MDM2 Control of p53 and E2F-1 Protein Stability
The ubiquitin ligase murine double minute clone 2 (MDM2) mediates ubiquitination and degradation of the tumor suppressor p53. The activation and stabilization of p53 by contrast is maintained by enzymes catalyzing p53 phosphorylation and acetylation. Casein kinase 1 (CK1) is one such enzyme; it stim...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2009
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2781653/ https://ncbi.nlm.nih.gov/pubmed/19759023 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.052647 |
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