A Central Role for CK1 in Catalyzing Phosphorylation of the p53 Transactivation Domain at Serine 20 after HHV-6B Viral Infection

The tumor suppressor protein p53 is activated by distinct cellular stresses including radiation, hypoxia, type I interferon, and DNA/RNA virus infection. The transactivation domain of p53 contains a phosphorylation site at Ser(20) whose modification stabilizes the binding of the transcriptional co-a...

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Detalhes bibliográficos
Main Authors: MacLaine, Nicola J., Øster, Bodil, Bundgaard, Bettina, Fraser, Jennifer A., Buckner, Carolyn, Lazo, Pedro A., Meek, David W., Höllsberg, Per, Hupp, Ted R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Mechanisms of Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2661408/
https://ncbi.nlm.nih.gov/pubmed/18669630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804433200
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