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Suppression of p38 MAPK and JNK via Akt-mediated Inhibition of Apoptosis Signal-regulating Kinase 1 Constitutes a Core Component of the β-Cell Pro-survival Effects of Glucose-dependent Insulinotropic Polypeptide
Glucose-dependent insulinotropic polypeptide (GIP) potentiates glucose-stimulated insulin secretion, insulin biosynthesis, and β-cell proliferation and survival. In previous studies GIP was shown to promote β-cell survival by modulating the activity of multiple signaling modules and regulating gene...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2781592/ https://ncbi.nlm.nih.gov/pubmed/19748889 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.060178 |
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